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” said another researcher Carol Ewing Garber.Dubai | Published: January 25 your kids may not be happy with you at all, the parents need to trust their kids to set their own boundaries.The kids do not want to see their parents spending all their time on the computer tablet or smartphone They hate using phone while driving Rather they want the parents to establish technology-related rules Most importantly the children want the parents to practice what they preach the researchers pointed out For news updates follow us on Facebook Twitter Google+ & Instagram For all the latest Lifestyle News download shlf1314n Express App More Related NewsWritten by Agencies | London | Published: January 11 2010 11:47 am Related News A new study has identified six genetic regions associated with a common type of arthritis called ankylosing spondylitisan international consortium jointly led by Oxford University reports in the journal Nature Genetics Two genes in particular show a strong connection with the diseasea release from the Oxford University said They are both involved in inflammatory processes in the bodywhich can now be investigated as targets for developing better treatments for ankylosing spondylitis Currently little is known about the causes of ankylosing spondylitis and the best available treatment is expensive and only provides symptom relief rather than being a cure “We have identified regions of our DNA that are strongly associated with susceptibility to ankylosing spondylitis” says Professor Paul Wordsworth of Oxford University’s Nuffield Department of OrthopaedicsRheumatology and Musculoskeletal Sciencesand one of the lead researchers of the study He said”We knew there was a strong genetic component to this diseaseand we now have the foundation we need for future research to pin down the genetic causes of this condition” Ankylosing spondylitis is a common cause of inflammatory arthritis affecting up to 200000 people in the UK alone and is a significant cause of work-related disability It typically first arises in young people around the age of 20 It affects the spineresulting in progressive stiffnessloss of movement and pain as the disease develops In the most severe casesit can lead to fusion of the spine through new bone formationwith people becoming fixed in a bent position looking at their feet Treatment typically involves physiotherapy and painkillers Potent new antibody (anti-TNF) therapies are effective in ankylosing spondylitisbut they only suppress symptoms of the disease rather than curing it and are needed life-long at a cost of around 10000 pounds per year “Cheaper or curative alternatives are a pressing need for this debilitating disease” says Professor Wordsworth There is known to be a strong genetic component to ankylosing spondylitis If a family member has the conditionyour chances of having ankylosing spondylitis rise to 1 in 10 The gene HLA-B27a gene involved in immune responses to infectionhas been known for three decades to be associated with the diseasebut there is convincing evidence that other genes are involved An international consortium of researchersled by the University of Queensland (Professor Matthew Brown)Oxford University and the University of Texas Health Science Center at Houstoncompared the genetic profiles of over 2000 people with ankylosing spondylitis with a control group of over 5000 people without the disease They scanned their entire genomes for any of 300000 genetic markers that repeatedly turned up in those with the disease and could reliably be associated with susceptibility to ankylosing spondylitis They found six regions of the genome that were associated with ankylosing spondylitis outside the large set of immune genes of which HLA-B27 is a member The two strongest associations were found in genes called ERAP1 and IL23R ERAP1 is involved in important pathways in the body that are thought to have roles in controlling inflammation IL23R has also been implicated in psoriasis and inflammatory bowel diseaseother conditions that also involve inappropriate inflammatory responses “We know something of the inflammatory processes in the body in which these two genes are involved” says Professor Wordsworth of Oxford University He added”The hope is now that we can look to develop drugs that inhibit these processes as potential new treatments for ankylosing spondylitis None of this work could have happened without the enthusiastic support of the members of the UK National Ankylosing Spondylitis Society” For all the latest Lifestyle News download shlf1314n Express App More Related News name it and she has done it all. Priyanka? chemical sensors, And like full-size necklaces, It is progressive.

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